Under the scorching test of high temperatures, your genes are quietly sounding the alarm!

In the sweltering midsummer, asphalt roads under the scorching sun seem on the verge of melting. The "sauna-like weather" with temperatures edging toward 40°C not only leaves people drenched in sweat but also subtly challenges the body's genetic defense barriers.

Did you know? In high-temperature environments, human gene expression undergoes subtle alterations—certain heat stress-related genes are activated, while DNA damage repair genes may become overburdened due to increased oxidative stress. Such changes at the microscopic level can induce heatstroke, cardiovascular diseases, and even accelerate cellular senescence. How can we decode these genetic signals to proactively safeguard health?

Genes' "help signals" in high heat

1.Activation of heat stress genes

In high-temperature environments, the human body initiates a series of heat stress responses, among which the expression of heat shock protein (HSP) genes increases significantly. These proteins can help cells repair protein structures damaged by high temperatures and maintain cellular functions. However, long-term exposure to high temperatures may lead to excessive expression of HSP genes, which can increase cellular burden and even trigger cell apoptosis

2.Changes in DNA Damage and Repair Genes

High temperatures increase the production of reactive oxygen species (ROS), leading to oxidative damage to DNA. Genes responsible for repairing DNA damage, such as BRCA1/2 and p53, may have reduced efficiency in high-temperature environments due to resource competition. This decline in repair capacity could raise the risk of gene mutations, which in turn may trigger cancer or other diseases.

The "invisible barometer" for health amid high temperatures

1.Activation of heat stress genes

Glycosylation is an important process in post-translational modification of proteins, and the structure of N-glycans directly affects protein function. In high-temperature environments, the glycosylation process may be affected, leading to protein dysfunction. For example, abnormal IgG glycosylation is closely associated with chronic inflammation and autoimmune diseases.

2.Changes in sugar chains and disease risk

Studies have demonstrated that high temperatures accelerate the degradation of glycans, leading to the accumulation of AGEs (Advanced Glycation End Products). AGEs are closely associated with the occurrence and progression of chronic diseases such as diabetes, cardiovascular diseases, and Alzheimer's disease.

*Technological support: The Glycome316 Glycomics Analyzer requires only 2 μL of serum and can generate high-precision glycan profiles within 45 minutes, helping identify glycosylation abnormalities and provide early warning of metabolic disease risks.

This summer, don't let high temperatures launch a "sneak attack" on your health! In high-temperature environments, traditional sequencing equipment often faces the challenge of sample degradation. However, the Honor series, equipped with rapid kits, shortens the amplification time to 75 minutes and boasts stronger analytical capability for degraded samples.

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